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Rosuvastatin in the prevention of venous thromboembolism

Posted May 29, 2009 at 11:45 AM, EDT by Samuel Goldhaber

What are the implications of the JUPITER trial's landmark findings in preventing venous thromboembolism? A 43% highly significant reduction in incidence and no increased bleeding risk with rosuvastatin 20 mg daily compared with placebo.  Where do we go next?  And what do we do now in clinical practice?

Please refer to the epublished JUPITER manuscript:  Glynn RJ et al.  A randomized trial of rosuvastatin in the prevention of venous thromboembolism.  N Engl J Med 2009; March 29.

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Given that there are a plethora of statin trials that have already been conducted, it would seem that, even though VTE may not have been a prespecified endpoint, one could go back to these databases and determine whether similar reductions in VTE were demonstrated versus placebo.


Posted by karen, Jun 02, 2009 at 09:14 AM, EDT
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This comment is a reply to karen (Jun 17, 2009 at 11:37 AM, EDT)

Der Dr Goldhaber,

DVT is a real threat as we know but this is the first time that we have discovered the statins to have a bearing on it.Congratulations to you from India!

Dr Sadasivan.


Posted by Prof Dr Sadasivan, Jun 17, 2009 at 11:37 AM, EDT
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the Virchow triad:
thrombosis is due to three factors-stasis
                      -hypercoaguabilité
                       -hyperviscosity
when you give a cause neuroleptic you demunition stasis by the seimulation nerve in vascular
so it always involve a antiagréguant or heparin with neuroleptics


Posted by Menad fatiha, Jun 03, 2009 at 12:31 PM, EDT
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perhaps a secondary prevention trial with a statin particularly in patients with recurrent VTE would be useful 
Posted by A G G Turpie, Aug 12, 2009 at 06:55 AM, EDT
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